Intel ISEF 2013 Finalist Profile

ME028 (Ho)
Protective Effects of Epigallocatechin-3-gallate against Hydrogen Peroxide-induced Apoptosis in Spinocerebellar ataxia, Type 3
Tzu-Hung Ho
National Taichung First Senior High School, Taichung, CHINESE TAIPEI

Spinocerebellar ataxia type 3 (SCA3), one of the most common ataxias worldwide, is caused by the expansion of a CAG triplet repeat located in the N-terminal coding region of the ATXN3 gene. Alleles of the ATXN3 gene that carry 13–44 CAG-trinucleotide repeats are present in normal individuals. Contrariwise, alleles with a CAG triplet repeat number of >50 are present in patients with SCA3. It is known as a dynamic mutation of trinucleotide repeat sequences of 63-85 of CAG, leading to form inclusion bodies in neuronal cells in the brain which is caused by polyQ. The present studies showed that EGCG can protect the apoptosis of SCA3 cell line by reducing the oxidative stress mediated by increasing the expression of Hsp70, Hsp60, and Bcl-2, but decreasing the expression of Bax.

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